Fig. 1.

Identification and validation of four oncomiRs in TNBC. a Illustration of the strategy to identify miRNAs that are associated with poor survival in TNBC patients. b Four microRNAs were found to have elevated expression that was associated with poor overall survival in 204 triple negative breast cancer patients by Kaplan-Meier analysis. c Expression levels of the four upregulated oncomiRs were examined in an independent cohort (GSE40267, N = 173). d Expression levels of the four oncomiRs were examined in 15 breast cancer cell lines, including MCF10A, five non-TNBC and nine TNBC cell lines by qPCR. The relative miRNA expression levels were normalized to U6. Mean ± SEM; ^* P < 0.05