Table 1.
Characteristics of study patients and corresponding relatives in families with more than one childhood cancer (FAM > 1)
| Study patient | Relative of study patient | ||||||
|---|---|---|---|---|---|---|---|
| Nr | Diagnosis | Gender | Age (years) | Diagnosis | Gender | Age (years) | Degree of relative |
| Leukemia | |||||||
| 1 | ALL | m | 4.3 | ALL | m | 4.2 | 5 |
| ALL | f | 3.9 | 5 | ||||
| 2 | ALL | f | 2.1 | ALL | f | 5.6 | 5 |
| ALL | f | 7.5 | 5 | ||||
| 3 | ALL | f | 6.0 | ALL | f | 14.1 | 3 |
| 4 | ALL | f | 4.4 | ALL | f | 5.3 | 1 |
| 5 | ALL | f | 2.3 | ALL | f | 1.3 | 4 |
| 6 | ALL | f | 3.2 | Leukemiaa | f | 13.0 | 2 |
| 7 | ALL | f | 8.1 | AML | m | 17.7 | 2 |
| 8 | ALL | f | 3.4 | Hodgkin lymphoma | m | 10.5 | 4 |
| 9 | ALL | f | 2.1 | Ganglioglioma | m | 7.0 | 1 |
| 10 | ALL | f | 8.6 | Ewing sarcoma | f | 8.2 | 5 |
| 11 | ALL | f | 1.6 | Retinoblastoma | f | 2.1 | 3 |
| 12 | AML | f | 12.4 | ALL | f | 4.5 | 4 |
| 13 | AML | f | 2.3 | AML | m | 0.3 | 4 |
| CNS tumors | |||||||
| 14 | Ependymoma | m | 11.7 | High grade glioma | f | 5.1 | 3 |
| 15 | Ependymoma | m | 6.8 | High grade glioma | f | 5.1 | 4 |
| 16 | Ependymoma | f | 10.2 | CNS tumora | f | 13.1 | 2 |
| 17 | Astrocytoma | m | 1.6 | Neuroblastoma | f | 0.9 | 1 |
| 18 | Astrocytoma | f | 16.0 | CNS undefined | f | 7.1 | 5 |
| 19 | Astrocytoma | f | 14.0 | Hodgkins lymphoma | f | 14.2 | 3 |
| 20 | Optic tract glioma | f | 4.6 | Ependymoma | f | 0.8 | 4 |
| 21 | Optic tract glioma | m | 2.2 | Wilms tumor | f | 1.6 | 6 |
| 22 | Ganglioglioma | f | 14.9 | Astrocytoma | m | 14.5 | 2 |
| 23 | Adenoma hypophysis | f | 12.8 | Neuroblastoma | m | 2.6 | 3 |
| Lymphomas | |||||||
| 24 | Hodgkin lymphoma | m | 8.3 | ALL | f | 5.6 | 4 |
| 25 | Hodgkin lymphoma | m | 13.5 | ALL | f | 4 | |
| 26 | Hodgkin lymphoma | f | 15.3 | Wilms Tumor | f | 13.2 | 3 |
| Ewing sarcoma | m | 13.2 | 3 | ||||
| 27 | Hodgkin lymphoma | f | 17.0 | CNS tumora | m | 0.0 | 3 |
| 28 | Burkitt lymphoma | m | 14.5 | Astrocytoma | f | 0.9 | 5 |
| 29 | Burkitt lymphoma | m | 16.1 | Rhabdomyosarcoma | m | 9.1 | 2 |
| 30 | Anaplastic large cell lymphoma | m | 12.9 | Hepatoblastoma | m | 0.9 | 5 |
| 31 | Diffuse large B-cell lymphoma | m | 16.5 | AML | m | 8.0 | 3 |
| Other diagnoses | |||||||
| 32 | Hepatoblastoma | f | 2.6 | Hodgkin lymphoma | m | 11.7 | 3 |
| 33 | Langerhans cell histiocytosis | m | 4.3 | Langerhans cell histiocytosis | m | 2.7 | 1 |
| 34 | Wilms tumor | m | 3.5 | ALL | m | 5.3 | 2 |
| 35 | Neuroblastoma | f | 0.3 | CNS tumora | f | 9.8 | 6 |
| 36 | Ganglioneuroblastoma | f | 2.7 | Osteosarcoma | f | 19.0 | 2 |
| 37 | Rhabdomyosarcoma | m | 2.2 | CNS tumora | f | 6.0 | 5 |
| Malign melanomaa | f | 17.5 | 4 | ||||
| 38 | Rhabdomyosarcoma | m | 4.4 | Astrocytoma | f | 3.9 | 5 |
| 39 | Retinoblastoma | f | 0.4 | Retinoblastom | m | 0.3 | 1 |
| 40 | Hepatoblastoma | f | 2.5 | Leukemiaa | m | <19b | 4 |
| 41 | Dysgerminoma | f | 12.6 | Leukemiaa | f | 5.0 | 4 |
Abbreviations: ALL acute lymphatic leukemia, AML acute myeloid leukemia, CNS central nervous system, m male, f female, age age at diagnosis
amicroscopic diagnosis not confirmed
bexact age unknown