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. 2017 Dec 20;3(12):eaar3952. doi: 10.1126/sciadv.aar3952

Fig. 2. In vivo genome editing provides therapeutic benefit to G93A-SOD1 mice.

Fig. 2

(A and B) Disease onset, (C and D) survival, (E) rotarod performance, and (F) weight of G93A-SOD1 mice injected with AAV9-SaCas9-hSOD1 (n = 7), AAV9-SaCas9-mRosa26 (n = 7), or AAV9-EGFP (n = 7) via facial vein at P0-P1. (E and F) Mean rotarod times and weights were normalized to average 56-day values for each group. Wild type (n = 6) indicates litter-matching control mice. Values are means and error bars indicate (A to C) SD and (E and F) SEM. ***P < 0.0005; **P < 0.005; (A, C) one-way or (E and F) two-way analysis of variance (ANOVA) followed by Tukey’s post hoc analysis.