Table 2.

Univariable and Multivariable Cox Models for Overall Survival

Variable	Univariable				Multivariable
	HR	95% CI	Pa	Overall Pa	HR	95% CI	P	Overall P
Age	1.03	1.02–1.05	<0.0001		1.03	1.02–1.04	<0.0001
Sex: male vs female	1.47	1.20–1.79	0.0002		1.36	1.11–1.66	0.003
Smoking status
Never	1.00	—	—	0.089
Former	1.16	0.88–1.54	0.3
Current	1.51	1.04–2.18	0.030
Extent of resection
Lobectomy/bilobectomy	1.00	—	—	<0.0001	1.00	—	—	<0.0001
Pneumonectomy	1.77	0.89–3.53	0.106		1.60	0.79–3.23	0.2
Segmentectomy	1.61	1.12–2.33	0.011		1.65	1.14–2.39	0.008
Wedge	2.05	1.54–2.72	<0.0001		2.09	1.55–2.81	<0.0001
Pathologic stage
IA	1.00	—	—	<0.0001	1.00	—	—	<0.0001
IB	1.86	1.48–2.34	<0.0001		1.50	1.16–1.93	0.002
IIA	2.67	1.81–3.94	<0.0001		2.24	1.47–3.39	0.0002
IIB/IIIA	3.96	2.92–5.38	<0.0001		3.15	2.15–4.63	<0.0001
Gross tumor size, cm	1.08	0.99–1.17	0.073		1.06	0.98–1.16	0.2
Lymphovascular invasion	1.52	1.22–1.90	0.0002		1.38	1.09–1.74	0.007
IASLC predominant subtype
Lepidic	1.00	—	—	0.016	1.00	—	—	0.3
Acinar	1.57	0.99–2.49	0.055		1.35	0.84–2.17	0.2
Papillary	1.74	1.08–2.81	0.023		1.45	0.90–2.36	0.13
Micropapillary	2.41	1.41–4.11	0.001		1.78	1.02–3.11	0.044
Solid	1.89	1.15–3.10	0.012		1.51	0.90–2.52	0.12
Architectural grade
Low	1.00	—	—	0.008
Intermediate	1.63	1.04–2.56	0.033
High	2.05	1.27–3.30	0.003
BRMS1 score: low vs high	1.37	1.12–1.67	0.002		1.36	1.11–1.67	0.003

CI, confidence interval; HR, hazard ratio.

^aP is from a model stratified by pathologic stage.