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. Author manuscript; available in PMC: 2019 Jan 5.
Published in final edited form as: J Mol Biol. 2017 Nov 11;430(1):33–40. doi: 10.1016/j.jmb.2017.11.002

Table 1.

Self-dissociation constants (KD) of HdeA and HdeA E37Q, measured by aITC or bMST. Enthalpy of dimer to monomer transition of from ITC experiment at pH 2.3: 10.6 ± 0.3 kcal/mol.

WT HdeA
KD (μM)
pH Experimental Simulated
2 - 84
2.3 a64 ± 8 -
4 b1.2 ± 0.2 2.5
5 b0.64 ± 0.17 0.7
6 b0.75 ± 0.31 1.0
7 b2.2 ± 0.6 1.5
HdeA E37Q
KD (μM)
pH Experimental Simulated
5 b0.55 ± 0.1 -
7 b0.49 ± 0.1 -

MD simulation values taken from Ahlstrom et al. [8].