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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Mol Cell Biochem. 2017 Jun 20;437(1-2):81–97. doi: 10.1007/s11010-017-3097-7

Table 1.

The genes associated with JAK/STAT pathway of inflammation used as input to NetworkAnalyst.

Activity Genes
Janus Kinase Activity JAK1, JAK2, JAK3, TYK2
STAT Family STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6
Receptors CSF1R, CSF2RB, EGFR, EPOR, F2R, GHR, IFNAR1, IFNGR1, IL10RA, IL2RA, IL2RG, IL4R, IL6ST, INSR, MPL, PDGFRA, SH2B1
Phosphorylation F2, F2R, IL20, PPP2R1A, PRLR, STAT1
Regulators HMGA1, SMAD3, SLA2, SPI1, STAT3, JUNB, SP1, USF1, PIAS1, YY1, SMAD1, SMAD5, CEBPB, CRK, GATA3, IRF1, IRF9, JUN, MYC, NFKB1, NR3C1, PPP2R1A, SMAD2, SMAD4
STAT induced genes CXCL9, IRF1, NOS2, A2M, BCL2L1, CDKN1A, CRP, FAS, MMP3, MYC, SOCS1, FCGR1A, IFNG, MYC, CCND1, CDKN1A, IL2RA, OSM, GATA3, GBP1, OAS1
Negative Regulators PIAS1, PIAS2, PTPN1, PTPRC, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5