Table 1.
Characteristics of population (n = 52)
| Total n = 52 |
Peak Edi < 2 µV n = 18 |
Peak Edi > 2 µV n = 34 |
|
|---|---|---|---|
| Age (months) | 10 (2–42) | 21 (1–135) | 6 (2–29) |
| Weight (kg) | 6.5 (4.3–17.4) | 11 (4.8–38.4) | 5.3 (4.0–12.0) |
| Male, n (%) | 31 (60%) | 11 (61%) | 20 (59%) |
| Days between admission and inclusion | 4 (1–10) | 3 (1–7) | 4 (1–10) |
| Days between MV initiation and inclusion | 3 (1–7) | 2 (1–6) | 4 (2–7) |
| Main reasons for PICU admission, n (%) | |||
| Respiratory failure | 31 (60%) | 5 (28%) | 26 (76%)* |
| Including bronchiolitis | 11 (21%) | 1 (6%) | 10 (29%) |
| Hemodynamic failure | 3 (6%) | 2 (11%) | 1 (3%) |
| Neurologic disorder | 9 (17%) | 6 (33%) | 3 (9%) |
| Metabolic disorder | 2 (4%) | 0 (0%) | 2 (6%) |
| Trauma | 2 (4%) | 2 (11%) | 0 (0%) |
| Postoperative admission | 5 (10%) | 3 (17%) | 2 (6%) |
| Chronic condition, n (%) | |||
| Respiratory disease | 8 (15%) | 2 (11%) | 6 (18%) |
| Cardiac disease | 9 (17%) | 3 (17%) | 6 (18%) |
| Neurological disease | 11 (21%) | 4 (22%) | 7 (21%) |
| Immuno-oncologic disease | 3 (6%) | 0 (0%) | 3 (9%) |
| Clinical status | |||
| PIM-2 score | 1.7 (0.8–4.3) | 2.3 (0.9–4.5) | 1.6 (0.8–4.4) |
| PELOD score | 2 (1–1) | 1 (1–11) | 1 (1–11) |
| Set respiratory rate, min−1 | 25 (20–35) | 23 (14–38) | 31 (25–42)* |
| Measured respiratory rate, min−1 | 29 (20–36) | 20 (15–29) | 34 (28–40)* |
| pH | 7.40 (7.35–7.42) | 7.40 (7.36–7.43) | 7.39 (7.34–7.43) |
| PaCO2, mmHg | 46 (42–53) | 42 (38–47) | 48 (45–57)* |
| HCO3 −, mmHg | 28 (24–32) | 27 (23–30) | 30 (25–33) |
| PEEP, cmH2O | 5 (5–6) | 5 (5–5) | 5 (5–6) |
| FiO2 | 0.35 (0.29–0.41) | 0.30 (0.24–0.35) | 0.35 (0.30–0.50) |
| Comfort score | 13 (10–15) | 11 (8–13) | 15 (12–16)* |
| Score sedation | 11 (6–21) | 10 (1–14) | 15 (6–25) |
| Edi analysis | |||
| Peak inspiratory Edi, µV | 3.6 (1.2–7.6) | 1.1 (0.6–1.3) | 6.6 (3.8–11.5) |
| Tonic expiratory Edi, µV | 0.7 (0.4–1.9) | 0.4 (0.3–0.5) | 1.1 (0.7–2.5) |
Data are expressed as median (interquartile range) or n (%)
Edi electrical activity of the diaphragm, MV mechanical ventilation, PICU pediatric intensive care unit, PEEP positive end-expiratory pressure
*Significant difference between the two groups (p < 0.05)