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. 2017 Dec 20;7:17897. doi: 10.1038/s41598-017-18236-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ONL count in normal and mutant retinas. (A1–2) Biaxial spidergraphs of outer nuclear layer thickness in the nasal-temporal and superior-inferior meridians for normal, rcd1 and xlpra2 retinas. H&E stained photomicrographs illustrating ONL thickness differences in the nasal, temporal, superior and inferior meridians of retina in a (B1–4) normal dog, (C1–4) rcd1 dog, and (D1–4) xlpra2 dog at 3000 ± 500 microns from the optic nerve head. RPE: Retinal Pigment Epithelium; ONL: Outer Nuclear Layer; INL: Inner Nuclear Layer; GCL: Ganglion Cell Layer; ONH: Optic Nerve Head.