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. 2017 Dec 20;7:17897. doi: 10.1038/s41598-017-18236-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immunohistochemical localization of select pathway proteins in normal and mutant retina. (A1–3) Complement component C3; (B1–3) Complement component and component of the membrane attack complex (MAC) C9; (C1–3) Inflammasome component NLRP3; (D1–3) Apoptosis executor and IL1β activator protein Caspase-1 (CASP1); (E1–3) TNF superfamily receptor TNFRSF1B; (F1–3) Cell surface death receptor FAS; (G1–3) Transcription factor of NFκB family, RELA (p65); (H1–3) Transcription activator protein of STAT family, STAT3; (I1–3) Anti-apoptotic protein BIRC3. RPE: Retinal Pigment Epithelium; ONL: Outer Nuclear Layer; OPL: Outer Plexiform Layer; INL: Inner Nuclear Layer; GCL: Ganglion Cell Layer.