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. 2017 Dec 20;7:17951. doi: 10.1038/s41598-017-18344-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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4-Br-BnIm rescued IOP and reduced myocilin accumulation in Tg-MYOC^Y437H mice. (a) IOP was measured biweekly over 12 weeks of treatment with vehicle or 4-Br-BnIm. Statistical analysis was carried out using one-way ANOVA with Bonferroni post-hoc test. *P < 0.05, ***P < 0.001. WT + vehicle (n = 3) WT + 4-Br-BnIm (n = 3), Tg-MYOC^Y437H + vehicle (n = 6), Tg-MYOC^Y437H + 4-Br-BnIm (n = 7). (b) Representative images depicting myocilin accumulation (red) in the trabecular meshwork (TM). TM, Schlemm’s canal (SC) and ciliary body (CB) are labeled. DAPI is used as a nuclear counterstain (blue). Scale Bar = 20 µm. (c) Quantification of myocilin levels. Statistical analysis was carried out using one-way ANOVA with Bonferroni post-hoc test. **P < 0.01, F = 5.77, df = 14. WT + vehicle (n = 2) WT + 4-Br-BnIm (n = 3), Tg-MYOC^Y437H + vehicle (n = 5), Tg-MYOC^Y437H + 4-Br-BnIm (n = 5).