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. 2017 Dec 20;7:17951. doi: 10.1038/s41598-017-18344-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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4-Br-BnIm reversed the light-adapted response phenotype in transgenic Tg-MYOC^Y437H mice and protects RGCs. (a) Light-adapted electroretinography (LA-ERG) tracings of WT and Tg-MYOCY437H mice without and with 4-Br-BnIm treatment. (b) Quantification of the PhNR from LA-ERG tracings. Statistical analysis was carried out using one-way ANOVA with Bonferroni post-hoc test. *P < 0.05, F = 2.48, df = 27. n values represent individual mice. WT + vehicle (n = 2), WT + 4-Br-BnIm (n = 3), Tg-MYOC^Y437H + vehicle (n = 5), Tg-MYOC^Y437H + 4-Br-BnIm (n = 4). (c) Representative images showing DAB stained NeuN positive cells in a 350 µm length of RGC layer from the midperipheral region of the retina from each treatment group. Scale bars = 20 µm. (d) A representative whole eye section from a WT vehicle mouse, boxes identify the region of retina used in the quantitation of RGC density. (e) Quantification of RGC density normalized to a WT vehicle treated mouse. Statistical analysis was carried out using two-tailed unpaired t-test. *P < 0.05, t = 3.63, df = 4. WT + 4-Br-BnIm (n = 3), Tg-MYOC^Y437H + vehicle (n = 3), Tg-MYOC^Y437H + 4-Br-BnIm (n = 3).