Table 1.

Estimation of binding affinities and the allosteric characteristics of pairs of GPR84 agonists.

Agonista	Modulatorb	logα	logβ	pKA c	pKB d
compound-1	DIM	2.1 ± 0.07	-0.2 ± 0.05	6.7 ± 0.06	5.2 ± 0.04
DIM	compound-1	1.8 ± 0.08	1.14 ± 0.03	5.3 ± 0.04	6.9 ± 0.07
compound-1	3a	1.75 ± 0.05	-0.1 ± 0.02	6.8 ± 0.03	5 ± 0.04
3a	compound-1	1.43 ± 0.08	1.2 ± 0.06	4.83 ± 0.06	7.2 ± 0.05
C-10	DIM	1.4 ± 0.1	0.4 ± 0.07	3.3 ± 0.08	5.2 ± 0.03
DIM	C-10	1.3 ± 0.1	1.2 ± 0.05	5.2 ± 0.06	3.8 ± 0.06
embelin	DIM	1.22 ± 0.05	0.8 ± 0.02	5.5 ± 0.03	5.15 ± 0.03
DIM	embelin	1.12 ± 0.04	1.0 ± 0.03	5.1 ± 0.03	5.7 ± 0.02

^aAgonist is the compound used to generate concentration-response curve.

^bModulator is the compound used in defined concentrations.

^cpK_A are values estimated for the agonist.

^dpK_B are values estimated for the modulator.

Data are means ± SEM.