Table 2.
Classical LA and models that generalize classical LA for partial agonism.
| Method | Year published | biochemically interpretable | Comments | Tool |
|---|---|---|---|---|
| A. Classical Loewe (Concentration Additivity) | ||||
| Loewe3 | 1926 | ✓ | not applicable for marginal curves with different maximal effect | R package BIGL |
| B. LOF-test of null models | ||||
| GCA (Howard)19 | 2009 | assumes hill slope = 1 for the marginal curves | ||
| Scholze20 | 2014 | rescales curves to common effect levels | ||
| FLM23 | 2016 | special cases are compatible with Loewe | ||
| Loewe (Di Veroli)21 | 2016 | reverts to highest single agent where classical Loewe is undefined | MATLAB Combenefit | |
| BIGL | 2017 | ✓ | R package BIGL | |
| C. Response surface capture models | ||||
| Harbron22 | 2010 | explores multiple null models | ||
| BRAID24 | 2016 | BRAID additivity surface is not Loewe additive | R packages braidrm and braidReports | |