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. 2017 Dec 20;7:17890. doi: 10.1038/s41598-017-17973-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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cycG mutants ameliorate the effects of p53 overexpression in the eye. (a) Overexpression of UAS-p53 with ey-Gal4 impedes eye development. Effects on eye size were grouped into four categories: 1 (black): no eye/pinhead eye; 2 (magenta): small eye; 3 (blue): smaller than wild type; 4 (green): wild type appearance. Scanning electron micrographs show examples. Size bar, 200 μm. (b) ey::p53 overexpression in the background of homozygous cycG mutants, genotypes are indicated. Eye phenotypes of the respective flies were categorized and fractions colour-coded as above. Genotypes are: UAS-lacZ/+; ey-Gal4/+control, UAS-p53/+; ey-Gal4/TM6B, UAS-p53/+; ey-Gal4 cycG ^HR7/cycG ^HR7, UAS-p53/+; ey-Gal4 cycG ^eoC/cycG ^eoC. (c) Combined overexpression of p53 and CycG in the eye anlagen; genotypes are indicated. Phenotypes were categorized as above. Genotypes are: UAS-lacZ/+; ey-Gal4/+control, UAS-p53/+; ey-Gal4/TM6B, UAS-lacZ/+; UAS-p53/+; ey-Gal4/TM6B, UAS-p53/UAS-CycG; ey-Gal4/TM6B. n: total number of analysed eyes is given below each column.