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. 2017 Dec 20;7:17925. doi: 10.1038/s41598-017-17622-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ANXA1 regulates syngeneic 4T1 tumour growth and metastasis in vivo. (A) BALBc WT and ANXA1^−/− mice were injected with 4T1 murine breast cancer cells containing a luciferase promoter into the mammary fat pad. Tumour volumes were calculated by LxWxW/2. (B) Bioluminescence imaging for mice from control and ANXA1^−/− group at week 1, 3 and 5 post-injection. (C) Representative bioluminescence image and pictures from lungs, liver and spleen after week 6 post-injection. (D) Survival curves were plotted for both groups (n = 6–8 per group, repeated twice). (E) Analysis of the percentage of CD45+ cells which are CD11b+. The percentage of (F) CD86+ (M1) or (G) CD206+ (M2) macrophages obtained from CD11b+ CD45+ population. Data shown are mean ± SD (n = 4). ****P ≤ 0.001, ANOVA.