Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Dec 20;7:17888. doi: 10.1038/s41598-017-17982-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Serum MMP-9 levels in patients participating to the dose escalating study (NCT01910649) and open label extension study with drisapersen (study 114673). (A) Box plots show comparable serum MMP-9 concentration in DMD natural history cohorts (patients belonging to the 3 natural history cohorts pooled together) and the baseline visit of DMD patients treated with drisapersen. (B) Scatter plot representing serum MMP-9 concentration (y-axis) with follow-up time (x-axis) in 12 DMD patients treated with drisapersen. MMP-9 levels significantly decrease over time (p < 10⁻³). (C) Histogram showing the age distribution of the 3 longitudinal cohorts. Mean, standard deviation and counts are reported for each cohort. (D) Scatter plots showing the increase of MMP-9 levels over time in the 2 natural history cohorts and the decrease of MMP-9 in the drisapersen treated cohort. All longitudinal samples in the same age range are included in this graph. Each dot represents a longitudinal measurement. Colors are specific for cohorts. Lines represent follow-up time as estimated by the fixed effects of the simplified linear mixed model only including follow-up time.