Table 2.

Hazard ratios of cardiovascular diseases and all-cause mortality by estimated glomerular filtration rate and proteinuria.

	eGFR(ml/min/1.73 m2)					Proteinuria
	≥90	60–89	45–60	<45	P for trend	No	Yes
CVDs
No. of cases	197	437	138	41		685	128
Incidence rate/1000 person-year	10.8	13.1	15.0	14.9		12.1	18.8
Crude model	Ref.	1.37(1.14–1.64)	1.77(1.38–2.26)	1.86(1.30–2.67)	<0.01	Ref.	1.54(1.28–1.87)
Model 1	Ref.	1.11(0.92–1.34)	1.18(0.91–1.54)	1.24(0.85–1.81)	0.16	Ref.	1.44(1.19–1.74)
Model 2	Ref.	1.08(0.88–1.33)	1.04(0.78–1.39)	0.98(0.64–1.50)	0.97	Ref.	1.25(1.02–1.54)
Model 3	Ref.	1.08(0.88–1.32)	1.04(0.78–1.40)	1.00(0.63–1.50)	0.88	Ref.	1.27(1.03–1.56)
All-cause mortality
No. of cases	175	465	213	64		716	201
Incidence rate/1000 person-year	9.5	13.8	23.4	24.1		12.5	30.2
Crude model	Ref.	1.86(1.54–2.24)	3.76(3.00–4.72)	4.41(3.23–6.02)	<0.01	Ref.	2.59(2.21–3.03)
Model 1	Ref.	1.10(0.90–1.33)	1.38(1.08–1.77)	1.52(1.10–2.11)	<0.01	Ref.	2.32(1.98–2.72)
Model 2	Ref.	1.04(0.84–1.27)	1.35(1.04–1.77)	1.66(1.17–2.37)	<0.01	Ref.	2.32(1.95–2.75)
Model 3	Ref.	1.03(0.84–1.27)	1.26(0.96–1.65)	1.50(1.04–2.15)	<0.01	Ref.	2.28(1.92–2.72)

Abbreviation: eGFR = estimated Glomerular Filtration Rate; CVD = Cardiovascular Diseases.

Model 1: adjusted for age, gender.

Model 2: adjusted for age, gender, education, income level, smoking status, drinking status, physical activity frequency, salt intake, family history of myocardial infarction, family history of stroke, hypertension, dyslipidemia, atrial fibrillation, use of antihypertensive drugs, use of lowering lipid drugs, use of antidiabetes drugs, resting heart rate, fasting plasma glucose, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol.

Model 3: adjusted for the factors included in Model 2 plus uric acid, C-reactive protein, and serum creatinine.