Table 3.

Stratified analysis by gender for hazard ratios of cardiovascular diseases and all-cause mortality.

	eGFR (ml/min/1.73 m2)a					Proteinuriab
	≥90	60–89	45–60	<45	P for trend	No	Yes
Men
CVDs
Age-adjusted	Ref.	1.16(0.95–1.42)	1.20(0.90–1.59)	1.18(0.78–1.79)	0.25	Ref.	1.36(1.11–1.68)
Multivariable	Ref.	1.12(0.90–1.39)	1.04(0.76–1.43)	1.03(0.64–1.65)	0.85	Ref.	1.18(0.94–1.48)
All-cause mortality
Age-adjusted	Ref.	1.05(0.86–1.29)	1.31(1.00–1.70)	1.41(0.98–2.02)	0.01	Ref.	2.20(1.86–2.61)
Multivariable	Ref.	0.96(0.77–1.19)	1.21(0.91–1.61)	1.47(1.00–2.18)	0.03	Ref.	2.15(1.79–2.59)
Women
CVDs
Age-adjusted	Ref.	0.79(0.46–1.33)	1.13(0.57–2.25)	1.60(0.66–3.86)	0.29	Ref.	2.02(1.23–3.34)
Multivariable	Ref.	0.83(0.45–1.53)	1.41(0.61–3.25)	1.43(0.44–4.66)	0.36	Ref.	1.92(1.09–3.40)
All-cause mortality
Age-adjusted	Ref.	1.72(0.85–3.47)	2.37(1.05–5.34)	3.04(1.17–7.91)	0.02	Ref.	3.48(2.23–5.45)
Multivariable	Ref.	2.20(0.99–4.88)	3.49(1.36–8.96)	4.26(1.38–13.19)_)	0.01	Ref.	3.96(2.39–6.57)

Abbreviation: eGFR = estimated Glomerular Filtration Rate; CVD = Cardiovascular Diseases.

^aP interaction of gender and eGFR for CVDs is 0.26; P interaction of gender and eGFR for all-cause mortality is 0.64.

^bP interaction of gender and proteinuria for CVDs is 0.08; P interaction of gender and proteinuria for all-cause mortality is 0.03.

^cAdjusted for age, gender, education, income level, smoking status, drinking status, physical activity frequency, salt intake, family history of myocardial infarction, family history of stroke, hypertension, dyslipidemia, atrial fibrillation, use of antihypertensive drugs, use of lowering lipid drugs, use of antidiabetes drugs, resting heart rate, fasting plasma glucose, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, uric acid, C-reactive protein, and serum creatinine.