Table 1.
Overview of the Top 20 Most Relevant Genes and Proteins Based on Their Calculated Composite Scores and Correlations With Histopathologic Fibrosis Score
| Gene name | Expression change, logFC | Documented biomarker for NASH | Documented biomarker for hepatic fibrosis | Composite score | Correlation Sirius Red | Ensemble gene ID |
|---|---|---|---|---|---|---|
| SERPINE1 | 3.0 | Y | Y | 16.1 | 0.858 | ENSMUSG00000037411 |
| CCL2 | 2.0 | Y | Y | 11.2 | 0.853 | ENSMUSG00000035385 |
| COL1A1 | 2.4 | Y | Y | 10.5 | 0.862 | ENSMUSG00000001506 |
| THBS1 | 2.1 | Y | Y | 9.3 | 0.961 | ENSMUSG00000040152 |
| CXCL10 | 2.1 | Y | Y | 9.3 | 0.788 | ENSMUSG00000034855 |
| CCR2 | 1.7 | Y | Y | 9.3 | 0.975 | ENSMUSG00000049103 |
| CD14 | 1.9 | Y | Y | 8.6 | 0.851 | ENSMUSG00000051439 |
| IL1RN | 2.5 | Y | N | 8.4 | 0.749 | ENSMUSG00000026981 |
| TNC | 1.4 | Y | N | 6.5 | 0.890 | ENSMUSG00000028364 |
| SMPD3 | 2.7 | N | N | 6.5 | 0.880 | ENSMUSG00000031906 |
| PLAU | 1.3 | N | Y | 6.3 | 0.882 | ENSMUSG00000021822 |
| COL3A1 | 1.8 | Y | Y | 6.3 | 0.927 | ENSMUSG00000026043 |
| APOA4 | 2.6 | Y | N | 6.3 | 0.808 | ENSMUSG00000032080 |
| MMP12 | 5.2 | N | N | 6.2 | 0.842 | ENSMUSG00000049723 |
| ACE | 1.0 | Y | Y | 6.1 | 0.870 | ENSMUSG00000020681 |
| COL1A2 | 1.7 | N | Y | 6.1 | 0.914 | ENSMUSG00000029661 |
| TLR4 | 0.7 | Y | Y | 5.5 | 0.786 | ENSMUSG00000039005 |
| ITGAX | 2.2 | Y | N | 5.4 | 0.850 | ENSMUSG00000030789 |
| VCAN | 1.9 | N | N | 4.9 | 0.910 | ENSMUSG00000021614 |
| CLEC7A | 1.8 | N | N | 4.7 | 0.885 | ENSMUSG00000079293 |
N, no; Y, yes.