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. 2017 Aug 16;5(1):15–30. doi: 10.1016/j.jcmgh.2017.08.001

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

(A) Kaplan-Meier analyses representing the percent survival of irradiated HIF-1α^FL/FLand HIF-1α^FL/FLVillin^Cre+/-mice after 19 -Gy localized intestinal radiation exposure. (B) Representative microscopic alterations obtained in HIF-1α^FL/FL and in HIF-1α^FL/FLVillin-Cre^+/- mice 3 and 7 days after irradiation. Slides were stained with hematoxylin-eosin-saffron. Scale bar = 100 μm. (C) Radiation injury score in HIF-1α^FL/FL and in HIF-1α^FL/FLVillin-Cre^+/- mice 3 and 7 days after irradiation (n = 8–10 mice per group). (D) Radiation injury score in HIF-1α^FL/FL and in HIF-1α^FL/FLVillin-CreER^t2+/- mice treated with tamoxifen 3 and 7 days after irradiation (n = 6–8 mice per group). (E) Kaplan-Meier analyses representing the percent survival of irradiated HIF-1α^FL/FL and HIF-1α^FL/FLVillin^Cre+/- mice after 13-Gy total body irradiation (NS, P = .0513). NS, not significant.