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. 2017 Dec 5;113(11):2452–2463. doi: 10.1016/j.bpj.2017.09.017

Figure 1.

Figure 1

The averaging effect of MSD calculation within the trajectory overlooks transient confinement periods. (A) Brownian simulated trajectories without (A1), with one period of confinement (in red) of 3 s in a confinement area of 50 nm in diameter (A2), with one period of confinement of 5 s in a confinement area of 100 nm in diameter (A3) or always confined in an area of 100 nm in diameter (A4). (B) MSD values of the simulated trajectories in (A) (mean ± SE). (C) Brownian simulated trajectories with three periods of confinement (in color) in 30-nm-diameter areas that were distanced (C1), apposed (C2), or colocalized (C3). (On the right) Minimum circles containing each confinement period (in colors) or the whole trajectory (gray). (D) MSD values of the simulated trajectories in (C) and of trajectory A1 for comparison (mean ± SE). To see this figure in color, go online.