Table 5.
Efficacy of blood pleurodesis for spontaneous pneumothorax (PSP and SSP) via chest drain
| Study author | Year | Study design | Total number of cases | PSP or SSP? (n) | Intervention (n) | Intervention recurrence rate (95% CI) |
Control/reference arm (n)? | Control/reference recurrence rate (95% CI) |
Follow-up period (months) |
OR (vs control/reference) (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| Prospective series | ||||||||||
| Cagirici48 | 1998 | Prospective series | 167 | PSP (116) SSP (51) |
Blood via chest drain (32) | 15.6% (6.0% to 40.6%) | Drainage only (135) | 28.1% (19.3% to 41.0%) | 12–48 | 0.47 (0.17 to 1.32) |
| Ando66 | 1999 | Prospective series | 11 | SSP (11) | Blood via chest drain (11) | 18.2% (3.9% to 84.1%) | – | – | 2–24 | – |
| Retrospective series | ||||||||||
| Aihara36 | 2011 | Retrospective case series | 36 | SSP (36) | Blood via chest drain (22) | 36.4% (15.3% to 86.7%) | Talc (14) | 21.4% (6.0% to 76.8%) | 15MN | 2.10 (0.45 to 9.81) |
| Evman50 | 2016 | Retrospective case series | 31 | SSP (31) | Blood via chest drain (31) | 16.1%* (6.2% to 42.0%) |
– | – | 29MN | – |
| Robinson49 | 1987 | Retrospective case series | 25 | Unclear | Blood via chest drain (25) | 16.0% (5.5% to 46.6%) | – | – | 24–132 | – |
Follow-up range shown if no average given.
*Includes early treatment failures.
MN, mean; PSP, primary spontaneous pneumothorax; SSP, secondary spontaneous pneumothorax.