Table S1.
Changes in hemodynamic, respiratory and metabolic variables after vasopressin infusion – global analysis.
| Variables | T0 (n=18) | T1 (n=18) | T2 (n=15) |
|---|---|---|---|
| Norepinephrine (μg/kg/min) | 0.41 (0.23, 0.90) | 0.31 (0.09, 0.76)* | 0.56 (0.23, 0.85)* |
| Heart rate (bpm) | 107.4±19.7 | 102.7±19.9* | 110.53±18.9* |
| MAP (mmHg) | 72.56±6.2 | 72.7±4.4 | 70.4±4,0 |
| CVP (mmHg) | 11.6±5.0 | 11.8±4.6 | 11.5±4.5 |
| PAOP (mmHg) | 9.6±4.5 | 10.6±3.7 | 9.0±4.2 |
| mPAP (mmHg) | 27.6±8.0 | 26.9±7.4 | 26.7±7.5 |
| CO (L/min) | 7.8±2.9 | 6.7±2.4* | 7.1±2.2* |
| CI (L/min.m2) | 4.4±1.2 | 3.7±0.9* | 4.0±0.8* |
| SI (ml/beat/m2) | 40.8±12.4 | 36.9±10.6 | 37.0±9.6 |
| PPV (%) | 5.0 (3.0, 10.5) | 4.0 (2.1, 8.7) | 4.7 (4.0, 5.7) |
| DO2 (ml/min) | 813.5 (676.2, 1153.0) | 738.5 (595.5, 939.5)* | 740.0 (643.0, 1048.0) |
| VO2 (mL/min) | 188.0 (142.0, 246.0) | 171.0 (140.0, 203.0)* | 196.0 (164.0, 225.0)* |
| Extraction rate (%) | 24.6±7.1 | 25.6±7.9 | 25.0±7.1 |
| PEEP (cmH2O) | 9.6±3.6 | 9.6±3.6 | 9.5±3.9 |
| FiO2 (%) | 0.40 (0.40, 0.50) | 0.40 (0.40, 0.50) | 0.4 (0.4, 0.5) |
| pO2/FiO2 ratio | 231.2 (169.4, 263.5) | 222.5 (187.6, 255.7) | 203.0 (185.0, 231.0) |
| Lactate (mg/dL) | 30.3±17.3 | 27.6±15.8 | 29.6±15.4 |
| a-vCO2 (mmHg) | 3.7 (2.5, 4.7) | 4.6 (3.2, 6.5) | 4.7 (4.0, 5.7) |
| Urine output (ml/kg/h) | 0.2 (0.0, 1.4) | 0.1 (0.0, 0.4) | 0.0 (0.0, 0.5) |
| SvO2 (%) | 73.6±6.5 | 70.9±7.7 | 72.4±6.7 |
| Haemoglobin (g/dL) | 9.0±1.4 | 8.8±1.4 | 8.8±1.5 |
Time points are defined as before (T0), during (T1) and after (T2) vasopressin infusion. MAP, mean arterial pressure; CVP, central venous pressure; PAOP, pulmonary artery occluded pressure; PAP, pulmonary artery pressure; CO, cardiac output; CI, cardiac index; SI, systolic index; PPV, pulse pressure variation; DO2, oxygen delivery; PEEP, positive end expiratory pressure; FiO2, fraction of inspired oxygen; pO2, oxygen partial pressure; ΔCO2, venous-arterial CO2 gradient; SvO2, oxygen mixed venous saturation. Data are expressed as number (%), mean±standard deviation or median (25%, 75%).
*
p<0.05 vs. previous time point.