Table 2.
pEC50 and Emax values for noradrenaline and phenylephrine in the presence of AZM475271 (10 μM), PP2 (10 μM), PF573228 (100 μM) or solvent
| pEC50 (M) | Emax (% KCl) | |||
|---|---|---|---|---|
| noradrenaline | phenylephrine | noradrenaline | phenylephrine | |
| DMSO | 5.285 ± 0.170 | 5.291 ± 0.109 | 174 ± 9.9 | 155 ± 28.4 |
| AZM475271 | 5.014 ± 0.213 | 4.974 ± 0.114 | 129 ± 11.1* | 83 ± 8.9* |
| DMSO | 5.16 ± 0.185 | 5.201 ± 0.085 | 149 ± 10.5 | 108 ± 11.6 |
| PP2 | 5.028 ± 0.161 | 5.073 ± 0.122 | 108 ± 12.2* | 77 ± 7.3* |
| PP2 | 5.048 ± 0.120 | 4.746 ± 0.111 | 147 ± 18.6 | 127 ± 40.7 |
| PP2 + PF573228 | 4.252 ± 0.196** | 4.469 ± 0.199 | 163 ± 13.2 | 99 ± 70.8 |
Values were obtained by curve fitting of each single experiment. Values in the table represent means ± SEM from all experiments (* P < 0.05 vs. corresponding DMSO control, ** P < 0.05 vs. corresponding PP2 series). Number of experiments for each series is identical to those in Figure 5.