Table 4.

Select studies of clonal status of parathyroid tumors in PHPT

Author	Year	N	HPT Type	Method	Ratio M:P (%P)
Fiaklow	1977	3*	Primary	G-6-PD	0:4 (0)
Arnold	1988	8	Primary	HPRT RFLP	6:2 (25)
Friedman	1989	34	Primary	Ch11 LOH	9:25 (73)
Shan	1997	8	Primary	HUMARA me-PCR	7:1 (12)
Sanjuan	1998	13**	Primary	HUMARA me-PCR	2:11 (85)
Shi	2014	14	Primary	HUMARA/PGK me-PCR	9:5 (36)
Present study	2017	119***	Primary	HUMARA/PGK me-PCR	64:55 (46)

^*4 tumors from 3 patients;

^**8 patients with adenomas + 5 patients with hyperplasia;

^***57 pts with “unclear” clonal status result; (G-6-PDH = glucose-6 phosphate dehydrogenase; HPRT RFLP = hypoxanthine phosphoribosyltransferase restriction-fragment-length-polymorphism; Ch11 LOH = chromosome 11 loss of heterozygosity; HUMARA me-PCR = Human androgen receptor gene methylation-sensitive PCR; PGK me-PCR = Phosphoglycerate kinase gene methylation-sensitive PCR