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. 2017 Dec 20;16:250. doi: 10.1186/s12944-017-0641-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The effect of mevalonate (column B), FPP (column C), and GGPP (column D) on statin-mediated GFP-K-Ras protein translocation in the human pancreatic cancer cells. MiaPaCa-2 human pancreatic cancer cells expressing GFP-K-Ras were treated with statins (20 μM) together with mevalonate (600 μM), FPP (17 μM) or GGPP (17 μM), respectively, for 24 h. MiaPaCa-2 cells treated only with statins (column A) were used as the control of the statins’ effect on GFP-K-Ras protein localization. Simva = simvastatin; FPP = farnesyl pyrophosphate; GGPP = geranylgeranyl pyrophosphate