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. 2017 Oct 25;15(1):278–284. doi: 10.3892/ol.2017.7264

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Various localizations of TET1 protein are associated with 5hmC status in human gastric cancer. (A) TET1 protein was exclusively expressed in the cytoplasm (left panel), in the cytoplasm and nucleus (middle panel) and predominantly in the nucleus (right panel) (magnification, ×100). (B) The results of immunohistochemistry revealed that nuclear exclusion of TET1 protein was associated with 5hmC depletion in gastric cancer tissues (magnification, ×100). (C) Nucleic TET1 protein expression was significantly associated with high 5hmC expression level in gastric cancer. (D) A schematic display of the structure of TET1 gene. An NES signal was identified in TET1 (aa877-889) using the ENS prediction tool (http://www.cbs.dtu.dk/services/NetNES/). TET, ten-eleven translocation; 5hmC, 5-hydroxymethylcytosine; NES, nuclear export signal; NLS, nuclear localization signals; NN, Neural Network; HMM, Hidden Markov Model.