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Pathway of 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) degradation catalyzed by enzymes encoded in the igr operon of M. tuberculosis. Metabolites in the pathway include 3-oxo-4,17-pregnadiene-20-carboxyl-CoA (3-OPDC-CoA) and 17-hydroxy-3-oxo-4-pregnene-20-carboxyl-CoA (17-HOPC-CoA). Ltp2 in complex with the DUF35 domain of ChsH2 is proposed to catalyze the retroaldol cleavage of 17-HOPC-CoA.
