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. 2017 Dec 20;12:35. doi: 10.1186/s13020-017-0159-4

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Decoction of Hedyotis diffusa (HD) relieves the acute inflammation in hepatitis mouse. a Administration of HD decoction blocked LPS/GALN-induced up-regulation of mRNA levels of CXCL1, TNF-α, IL-1β, MIP-2. b The treatment of HD decoction reduced the expressed levels of TNF-α, IL-1β, IL-6 and MCP-1 in liver of LPS/GALN-injected mice. c Alanine transaminase (ALT) level was measured in control or LPS/GALN- and LPS/GALN + HD-treated mouse. HD decoction significantly reduced the level of ALT (n = 5). d Aspartate transaminase (AST) level was measured in control or LPS/GALN- and LPS/GALN + HD-treated mouse. HD decoction significantly reduced the level of AST (n = 5). e Survival of hepatitis mouse was measured after treatment of HD decoction (n = 20, per group) within 20 days. f Effect of HD on LPS/GALN-mediated liver histopathologic changes