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. 2017 Dec 20;25:25. doi: 10.1186/s40199-017-0191-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Representative photomicrographs of hippocampal slices and quantitative analysis of the survived neurons in CA1 sub-regions. a: The viable round cells with distinct nucleus and nucleolus in sham-operated group, b: Dark-stained cells with dysmorphic or shrunken shape (black arrows) due to 10-min ischemia followed by 72 h reperfusion, c: Treatment with S-NLCs (containing 25 mg/kg of sesamol) attenuated I/R-induced neuronal damage, d: Free sesamol (25 mg/kg) failed to effectively prevent I/R-induced neuronal injury, e: Pre-treatment with LY294002 (25 μg/μl) abolished the ameliorative effects of S-NLCs (25 mg/kg), (scale bars: 50 μm). f: S-NLCs (20 and 25 mg/kg), but not sesamol, significantly increased the survived neurons in the hippocampal CA1 region. Pre-treatment with LY294002 (25 μg/μl) prevented the neuroprotective effects of S-NLCs. Data are expressed as mean ± SEM (n = 6). ^a P < 0.001 vs. sham or intact group, ^b P < 0.001 vs. sham, intact, I/R or I/R + vehicle groups. (I/R: ischemia/reperfusion, LY: LY294002, S-NLCs: sesamol-loaded nanostructured lipid carriers)