. 2017 Dec 20;25:25. doi: 10.1186/s40199-017-0191-z

Table 3.

Effects of sesamol or S-NLCs on the biochemical parameters following the ischemic insult

Groups	MDA (nM/mg protein)		GSH (nM/mg protein)		SOD (U/mg protein)		CAT (U/mg protein)
	1 h	8 h	1 h	8 h	1 h	8 h	1 h	8 h
Control OGD OGD + vehicle OGD + sesamol (20 μM) OGD + sesamol (40 μM) OGD + sesamol (80 μM) OGD + sesamol (100 μM) LY + OGD + sesamol (80 μM) LY + OGD + sesamol (100 μM) OGD + blank NLCs OGD + S-NLCs (20 μM) OGD + S-NLCs (40 μM) OGD + S-NLCs (80 μM) OGD + S-NLCs (100 μM) LY + OGD + S-NLCs (80 μM) LY + OGD + S-NLCs (100 μM)	0.53 ± 0.04 1.32 ± 0.10^ 1.37 ± 0.14^ 1.38 ± 0.23^ 1.22 ± 0.19^ 0.65 ± 0.06^& 0.59 ± 0.03^π 1.43 ± 0.09^ 1.28 ± 0.15^ 1.35 ± 0.16^** 1.15 ± 0.11^* 1.17 ± 0.08^* 0.58 ± 0.03^¥ 0.47 ± 0.04^∑ 1.23 ± 0.07^* 1.37 ± 0.19^**	0.57 ± 0.05 2.02 ±0.25^* 1.91 ±0.14^* 2.12 ±0.21^* 1.76 ±0.13^* 1.88 ±0.11^* 1.79 ±0.09^* 1.94 ±0.22^ 1.67 ±0.19^ 2.07 ±0.17^* 1.98 ±0.10^* 1.92 ±0.16^* 1.02 ±0.16^Ө 0.92 ±0.07^∞ 1.48 ±0.33^ 1.27 ±0.08^***	12.97 ± 1.19 7.13 ± 0.49^* 7.29 ± 0.57^* 7.92 ± 0.48^* 7.22 ± 0.45^* 10.62 ± 0.83^# 10.29 ± 0.52^∆ 7.56 ± 0.62^ 8.19 ± 0.62^ 7.58 ± 0.67^* 7.38 ± 0.81^* 8.25 ± 0.89^ 10.87 ± 0.55^$ 11.03 ± 0.42© 8.07 ± 0.24^* 7.58 ± 0.13^***	12.71 ± 0.93 3.81 ± 0.36^* 3.65 ±0.22^* 3.58 ± 0.17^* 3.81 ± 0.25^* 4.83 ±0.28^* 4.17 ±0.13^* 4.33 ±0.24^* 4.61 ±0.17^* 3.47 ±0.18^* 4.26 ± 0.39^* 4.75 ±0.17^* 6.67 ±0.59^@ 7.49 ± 0.38^£ 4.25 ±0.19^* 4.72 ±0.22^***	39.67 ± 2.94 24.94 ± 2.38^* 23.63 ± 1.82^* 23.02 ± 2.11^* 26.83 ± 1.96^ 37.06 ± 1.89^ω 36.94 ± 2.14^Ω 25.17 ± 1.03^* 23.86 ± 2.87^ 25.17 ± 2.34^* 27.70 ± 1.94^ 29.38 ± 1.33^* 35.33 ± 2.12^€ 34.52 ± 1.84^Ϙ 24.13 ± 1.08^ 22.96 ± 1.85^*	38.29 ± 1.87 18.77 ± 1.14^* 19.35 ± 1.29^* 19.83 ± 1.82^* 18.22 ± 2.16^* 21.63 ± 1.96^* 20.17 ± 1.07^* 18.73 ± 2.45^* 21.08 ± 1.66^* 18.16 ± 1.01^* 17.38 ± 1.64^* 20.52 ± 2.02^* 27.84 ± 2.14^ø 29.03 ± 1.23^ж 17.88 ± 1.13^* 21.32 ± 1.89^***	6.83 ± 0.44 2.44 ± 0.19^* 2.32 ± 0.25^* 2.45 ± 0.14^* 2.76 ± 0.27^* 4.28 ± 0.36^Φ 4.86 ± 0.19^Ҩ 2.34 ± 0.23^ 2.69 ± 0.14^* 2.36 ± 0.15^* 2.23 ± 0.15^* 3.42 ± 0.24^* 4.86 ± 0.27 ^β 4.73 ± 0.14^ȹ 3.11 ± 0.19^* 2.65 ± 0.27^**	6.88 ± 0.47 1.49 ± 0.18^* 1.53 ± 0.16^* 1.47 ± 0.13^* 1.64 ± 0.11^* 1.59 ± 0.16^* 1.73 ± 0.08^* 1.29 ± 0.18^ 1.55 ± 0.07^* 1.54 ± 0.12^* 1.71 ± 0.18^* 1.85 ± 0.21^* 2.83 ± 0.26^Џ 2.96 ± 0.23^ʉ 1.63 ± 0.09^* 1.96 ± 0.16^***

PC12 cells have been exposed to 1 and 8 h oxygen-glucose deprivation. Each value represents the mean ± SEM of six independent experiments

(MDA malondialdehyde, GSH reduced glutathione, CAT catalase, SOD superoxide dismutase, OGD oxygen-glucose deprivation, S-NLCs sesamol-loaded nanostructured lipid carriers, LY LY294002)

^* P < 0.05, ^** P < 0.01, ^*** P < 0.001 vs. control, ^{#, $,} ©^{, &, €, Ϙ, ∆, @, £, Ω} P < 0.05 vs. OGD and OGD + vehicle, ^{π, ¥, ∑, Ө, ω}P < 0.01 vs. OGD and OGD + vehicle, ^{∞, Φ, Ҩ, β, ȹ, ж} P < 0.001 vs. control, OGD, and OGD + vehicle, ^ø P < 0.01 vs. control and P < 0.05 vs. OGD and OGD + vehicle, ^{Џ, ʉ} P < 0.001 vs. control and P < 0.01 vs. OGD and OGD + vehicle