. 2017 Dec 20;25:25. doi: 10.1186/s40199-017-0191-z

Table 5.

Effects of sesamol or S-NLCs on the biochemical parameters in hippocampus following the global ischemia

Groups	MDA (nM/mg protein)	GSH (nM/mg protein)	SOD (U/mg protein)	CAT (U/mg protein)
Sham Intact I/R I/R + vehicle I/R + sesamol (5 mg/kg) I/R + sesamol (10 mg/kg) I/R + sesamol (20 mg/kg) I/R + sesamol (25 mg/kg) I/R + blank NLCs I/R + S-NLCs (5 mg/kg) I/R + S-NLCs (10 mg/kg) I/R + S-NLCs (20 mg/kg) I/R + S-NLCs (25 mg/kg) LY + I/R + S-NLCs (20 mg/kg) LY + I/R + S-NLCs (25 mg/kg)	0.92 ± 0.06 0.87 ± 0.09 2.12 ± 0.21^ 2.16 ± 0.19^ 2.09 ± 0.20^ 2.23 ± 0.18^ 1.93 ± 0.20^* 1.84 ± 0.19^* 2.03 ± 0.34^* 2.14 ±0.24^** 1.95 ± 0.15^* 1.29 ±0.15^Ω 1.08 ±0.12^# 2.13 ±0.16^** 1.99 ±0.22^*	1.98 ± 0.09 2.02 ± 0.18 0.96 ± 0.22^* 0.91 ± 0.15^* 0.98 ± 0.17^ 0.87 ± 0.15^* 1.04 ± 0.06^ 1.09 ± 0.13^ 1.01 ± 0.19^ 0.98 ± 0.15^ 0.93 ± 0.24^* 1.63 ± 0.09^Ұ 1.81 ± 0.07^∑ 0.93 ± 0.13^* 1.07 ± 0.09^**	5.77 ± 0.25 5.83 ± 0.19 3.31 ± 0.13^* 3.24 ± 0.21^* 3.13 ± 0.15^* 3.68 ± 0.25^* 3.60 ±0.37^* 3.79 ±0.19^* 3.31 ± 0.11^* 3.19 ± 0.20^* 2.77 ± 0.23^* 4.68 ± 0.19^Δ 4.97 ± 0.14^£ 3.07 ± 0.24^ 3.16 ± 0.11^***	4.69 ± 0.32 4.58 ± 0.54 2.49 ± 0.17^* 2.55 ± 0.22^* 2.63 ± 0.24^* 2.68 ± 0.18^* 2.77 ± 0.12^* 2.61 ± 0.15^* 2.83 ± 0.25^* 2.80 ± 0.16^* 3.13 ± 0.14^ 4.06 ± 0.29^Φ 4.29 ± 0.12^€ 2.66 ± 0.19^* 2.37 ± 0.98^***

S-NLCs, but not free sesamol, significantly attenuated the oxidative stress induced by the global ischemia. Data are presented as mean ± SEM (n = 6)

(I/R ischemia/reperfusion, NLCs nanostructured lipid carriers, S-NLCs sesamol-loaded NLCs, MDA malondialdehyde, GSH reduced glutathione, SOD superoxide dismutase, CAT catalase)

^*P < 0.05, ^** P < 0.01, ^*** P < 0.001 vs. sham or intact, ^ҰP < 0.05, ^{Φ, Δ, Ω, #, ∑, €}P < 0.01, ^£P < 0.001 vs. I/R or I/R + vehicle