Fig. 2.

Tenuigenin improved motor behavior and increased dopamine levels in MPTP acute model mice. a Experimental procedure and drug administration schemes. Black and long arrows represented the administration of tenuigenin, while red and short arrows represented the administration of MPTP. b Effects of tenuigenin on total move distance in each group. Locomotor activity in 60 min was detected and analyzed by Truscan2.0 system 3 days after MPTP injections. c Effects of tenuigenin on the duration of mice stayed on the rotating rod. Latency time was detected 3 days after MPTP injections. d DA, e DOPAC, and f HVA were analyzed by HPLC. g The ratio of (DOPAC + HVA)/DA which represented the rate of DA metabolism. n = 12 for each group. Data are expressed as mean ± SEM, one-way ANOVA, *p < 0.05, **p < 0.01, and ***p < 0.001 vs. saline group. ^# p < 0.05, ^## p < 0.01, and ^### p < 0.001 vs. MPTP group