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. 2017 Dec 20;14:256. doi: 10.1186/s12974-017-1036-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Tenuigenin attenuates microglia activation induced by LPS in SNc and suppress LPS-induced serum IL-1β production. a Immunostaining with Iba-1 to visualize the activation of microglia in the SNc of each group. Scale bar represents 200 μm (upper) or 50 μm (under). b Stereological counts of Iba-1-positive cells in the SNc of each group. c ELISA of IL-1β in serum of each group. n = 6 for each group. Data are expressed as mean ± SEM, one-way ANOVA, **p < 0.01 and ***p < 0.001 vs. saline group. ^# p < 0.05 and ^## p < 0.01 vs. LPS group