Table 2.
Hazard ratios and 95% CI for lifestyle factors and mortality risk among endometrial cancer survivors in NIH-AARP (n = 580)
| Deaths/total n | Model 1 HR (95% CI) | Model 2 HR (95% CI) | Model 3 HR (95% CI) | Model 4 HR (95% CI) | |
|---|---|---|---|---|---|
| BMI (kg/m2) | |||||
| 18.5–<25 | 21/172 | 1.00 | 1.00 | 1.00 | 1.00 |
| 25–<30 | 26/160 | 1.33 (0.75, 2.37) | 1.19 (0.66, 2.14) | 1.10 (0.61, 2.01) | 0.98 (0.53, 1.81) |
| 30–<35 | 21/133 | 1.30 (0.71, 2.39) | 1.11 (0.57, 2.16) | 0.97 (0.49, 1.92) | 0.89 (0.45, 1.79) |
| 35+ | 23/115 | 2.26 (1.23, 4.12) | 2.14 (1.08, 4.24) | 1.83 (0.90, 3.71) | 1.47 (0.71, 3.07) |
| p-trend | 0.021 | 0.057 | 0.172 | 0.404 | |
| MVPA (MET h/week) | |||||
| 0 | 36/174 | 1.00 | 1.00 | 1.00 | 1.00 |
| 0.1–<15 | 24/162 | 0.69 (0.42, 1.13) | 0.83 (0.48, 1.45) | 0.86 (0.49, 1.51) | 0.93 (0.54, 1.62) |
| 15+ | 31/244 | 0.70 (0.42, 1.15) | 0.72 (0.43, 1.21) | 0.74 (0.43, 1.24) | 0.87 (0.40, 1.09) |
| p-trend | 0.042 | 0.220 | 0.345 | 0.721 | |
| TV time (h/day) | |||||
| <3 | 31/240 | 1.00 | 1.00 | 1.00 | 1.00 |
| 3–4 | 25/182 | 0.94 (0.56, 1.60) | 0.88 (0.51, 1.51) | 1.25 (0.74, 2.10) | 1.21 (0.70, 2.10) |
| 5+ | 35/158 | 1.61 (0.97, 2.65) | 1.46 (0.86, 2.46) | 2.69 (1.28, 5.65) | 2.28 (1.05, 4.95) |
| p-trend | 0.057 | 0.168 | 0.026 | 0.082 | |
Model 1 was adjusted for the factor of interest only
Model 2 was additionally adjusted for age at diagnosis, tumor stage (localized, regional/distant), tumor grade (well, moderately, poorly differentiated), first course of treatment (yes/no for surgery, chemotherapy, and radiation), diabetes (yes/no), age at menarche (≤12, >12 years old), and hormone use at baseline (ever/never)
Model 3 was additionally adjusted for the other main exposures of interest (BMI, MVPA, and TV)
Model 4 was additionally adjusted for self-reported health status (excellent/very good, good, fair/poor)