Table 2.
Odds ratios for all factors associated with significant increased risk of peripheral T cell lymphoma and/or mycosis fungoides/Sézary syndrome
| Exposure category | PTCL | MF/SS OR (95 % CI) |
|---|---|---|
| Autoimmune disease | ||
| Psoriasis | 2.41 (1.15–5.04) | – |
| Systemic lupus erythematosus | 3.90 (1.24–12.3) | 5.03 (1.17–21.6) |
| Any T cell-activating disease | 1.95 (1.37–2.77) | 1.66 (1.00–2.75) |
| Celiac disease | 14.8 (7.27–30.2) | – |
| Systemic sclerosis/scleroderma | – | 8.87 (1.11–71.3) |
| Eczema | ||
| Any diagnosis | – | 2.38 (1.73–3.29) |
| Diagnosis within 10 years of NHL | – | 4.87 (2.15–11.02) |
| Cigarette smoking | ||
| Duration≥20 years | 1.75 (1.33–2.30) | 1.22 (0.84–1.77) |
| Duration≥40 years | – | 1.55 (1.04–2.31) |
| BMI 35–50 kg/m2 | – | 1.57 (1.03–2.40) |
| Family history of hematologic malignancy | ||
| Any | 1.86 (1.26–2.74) | 1.16 (0.68–1.98) |
| Leukemia | 1.84 (1.09–3.13) | 1.06 (0.49–2.29) |
| Multiple myeloma | 2.86 (0.98–8.37) | 6.11 (2.36–15.8) |
| Occupational history | ||
| Painter | 1.45 (0.73–2.88) | 3.42 (1.81–6.47) |
| General farm worker | 0.79 (0.40–1.56) | 2.07 (1.06–4.07) |
| General carpenter | – | 4.07 (1.54–10.8) |
Abbreviations: OR odds ratio, CI confidence interval, PTCL peripheral T cell lymphoma, MF/SS mycosis fungoides/Sézary syndrome, BMI body mass index