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. Author manuscript; available in PMC: 2019 Jan 15.
Published in final edited form as: Neuroimage. 2017 Oct 7;165:118–124. doi: 10.1016/j.neuroimage.2017.10.009

Table 4.

K1 and Total Distribution Volume (VT) values estimated with the one-tissue compartmental model (1TCM), along with VT values and Correlation between age and regional VT estimated using Logan analysis (t* =45 minutes) for [18F]ASEM PET imaging in humans(N=25).

ROI 1TCM
Logan
K1a
(mL cm−3 min−1)		 VTa
(mL cm−3)		 VTa
(mL cm−3)		 Rho (P value)b
Thalamus 0.36 ± 0.06 21.44 ± 4.68 22.78 ± 5.15 0.591 (0.002)*
Striatum 0.35 ± 0.06 21.82 ± 5.96 22.60 ± 5.97 0.778 (< 0.001)*
Hippocampus 0.27 ± 0.05 17.92 ± 3.38 19.77 ± 3.97 0.666 (< 0.001)*
Cerebellar CTX 0.36 ± 0.06 16.17 ± 3.32 16.92 ± 3.44 0.718 (< 0.001)*
Temporal CTX 0.30 ± 0.05 21.20 ± 3.68 22.30 ± 3.94 0.621 (0.001)*
Occipital CTX 0.38 ± 0.07 20.34 ± 3.48 21.44 ± 3.66 0.652 (< 0.001)*
Cingulate CTX 0.35 ± 0.06 20.78 ± 3.31 21.85 ± 3.51 0.610 (0.001)*
Frontal CTX 0.36 ± 0.07 20.62 ± 4.16 21.45 ± 4.19 0.581 (0.002)*
Parietal CTX 0.36 ± 0.06 21.70 ± 4.18 22.78 ± 4.35 0.670 (< 0.001)*
a

Presented as Mean ± Standard Deviation. Regional VT values were generated using metabolite-corrected arterial input function and 90 minute dynamic data.

b

Spearman’s rank correlation analysis was applied to each test of correlation between age and regional VT generated using Logan analysis. Cortex, CTX; Region of Interest, ROI.

*

P < 0.0056, which marks significance after applying Bonferroni correction for the nine regions tested.