Table 2.

Quality assessment of studies included in the meta-analysis

Reference	Trial name	Year	Method of randomization	Allocation concealment	Blinded	Withdrawal and dropout	Baseline	Quality level*
40	VANTAGE 008	2013	Centralized	Central office	Yes	Detailed criteria	Identical baseline	A
39	DOXIL-MMY-3001	2007	Centralized	Central office	No	Detailed criteria	Identical baseline	A
10	NCT00401843	2015	Centralized	Central office	Yes	Detailed criteria	Identical baseline	A
41	MMY 3021	2011	Centralized	Central office	No	Detailed criteria	Identical baseline	A
37	AMBER	2012	Centralized	Central office	Yes	Detailed criteria	Identical baseline	A
36	ENDEAVOR	2015	Centralized	Central office	No	Detailed criteria	Identical baseline	A
35	PANORAMA 1	2014	Centralized	Central office	Yes	Detailed criteria	Identical baseline	A
34	CASTOR	2016	Centralized	Central office	No	Detailed criteria	Identical baseline	A
33	NCT01478048	2016	Centralized	No details	No	Detailed criteria	Identical baseline	B
11	NCT00602511	2012	Centralized	Central office	No	Detailed criteria	Identical baseline	A
32	MM-010	2007	Centralized	Central office	Yes	Detailed criteria	Identical baseline	A
31	MM-009	2007	Centralized	Central office	Yes	Detailed criteria	Identical baseline	A
29	APEX	2009	No details	No details	No	Detailed criteria	Identical baseline	B
28	OPTIMUM	2012	No details	No details	No	Detailed criteria	Identical baseline	B
27	ASPIRE	2014	Centralized	Central office	No	Detailed criteria	Identical baseline	A
26	ELOQUENT-2	2015	Centralized	Central office	No	Detailed criteria	Identical baseline	A
42	TOURMALINE-MM1	2015	Centralized	Central office	Yes	Detailed criteria	Identical baseline	A
25	POLLUX	2016	Centralized	Central office	No	Detailed criteria	Identical baseline	A
24	MMVAR/IFM 2005-04	2012	No details	No details	No	Detailed criteria	Identical baseline	B

^*A, quality score of 4 to 5 of a total score of 5; B, quality score of 2 to 3 of a total score of 5.