Table 1.
Baseline Characteristics and Outcome
| Uncomplicated Malaria | Severe Malaria | P Value | |
|---|---|---|---|
| (n = 77) | (n = 203) | ||
| Age, years | 25 (20 to 40) | 32 (24 to 45) | .02 |
| Fever duration, days | 7.5 (6 to 10.5) | 7 (5 to 9) | .01 |
| Hematocrit, % | 31 (25 to 37) | 28 (22 to 35) | .03 |
| Plasma PfHRP2, ng/mL | 504 (171.2 to 1036) | 2565 (947 to 5278) | <.001 |
| Parasitemia, μL | 18 870 (6894 to 62409) | 138 380 (34 670 to 339 660) | <.001 |
| Base deficit, mmol/l | –1 (–3 to 1) | –7 (–11 to –4) | <.001 |
| BUN, mg/dl | 15 (11 to 25) | 41.2 (24 to 70) | <.001 |
| GCS | 15 (15 to 15) | 9 (7 to 12) | <.001 |
| Sex, % male | 74 | 69 | .41 |
| Previous malaria, % | 31 | 16 | .009 |
| Coma, % | NA | 70 | NA |
| Hyperparasitemia, % | NA | 28 | NA |
| Acidosis, % | NA | 34 | NA |
| Acute renal failure, % | NA | 24 | NA |
| Anemia, % | 13 | 21 | .15 |
| Jaundice, % | 33 | 38 | .46 |
| Died, % | NA | 33 | NA |
Brackets contain interquartile range. Dichotomous variables are defined as previously used [9]. Uncomplicated malaria parasitemia (n = 69). Abbreviations: PfHRP2, Plasmodium falciparum histidine-rich protein 1; BUN, blood urea nitrogen; GCS, Glasgow Coma Score; NA, not applicable; n, number of patients for whom data was available.