Table 4.
Patients with multiple visits (n=26)
| Run Times (seconds) | Visit 1 | Visit 2 | ||||
|---|---|---|---|---|---|---|
| All | No-OHE | Prior OHE | All | No-OHE | Prior OHE | |
| Total Off | 101.8±34.4 | 81.3±15.4 | 114.1±37.2† | 103.4±36.8 | 82.0±18.5 | 116.5±39.4† |
| Total On | 124.7±54.8 | 100.5±27.2 | 148.7±80.9† | 130.6±69.3 | 90.3±22.2* | 145.4±58.2† |
| OffTime+OnTime | 226.5±87.9 | 184.4±45.0 | 259.6±93.8† | 234.2±104.2 | 170.1±34.5* | 265.0± 118† |
| OnTime minus OffTime | 22.9±24.7 | 18.4±11.8 | 31.3±27.2† | 27.0±37.7 | 9.0±11.8* | 32.2±46.7† |
| Number of runs off state (median) | 5 | 5 | 5 | 5 | 5 | 5 |
| Number of Runs on state (median) | 6 | 6 | 6 | 6 | 6 | 6 |
| Off run 1 minus Off run 5 (median) | −0.31 | 0.11 | −1.54 | 0.10 | −0.23 | 0.43 |
| On run 1 minus On run 5 (median) | 0.78 | 0.76 | 0.80 | 0.10 | 0.51 | −0.15 |
OHE: overt hepatic encephalopathy. Fifteen patients had OHE while 11 patients did not have OHE; this was stable at both time points. Data in mean ± standard deviation unless mentioned otherwise *p<0.05 between visits 1 and 2 (Wilcoxon signed rank sum tests),†p<0.05 OHE vs. no-OHE (Kruskal-Wallis and t-tests). A positive run 1 minus run 5 score indicates lesser time spent in run 5 than run 1 reflecting learning over the test. Patients with prior OHE did not improve (decrease) their times, while those without OHE improved their times. No change in learning capability was seen over time within and between groups.