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Tumor-specific profiling of the accumulation of nanomedicines using companion nanoparticles. Companion magnetic nanoparticles (MNP) accumulate within tumors, and can be imaged to predict the accumulation of therapeutic nanoparticles (TNP)—a physical effect that is specific to the nanomedicine drugs. The MNPs did not predict free drug accumulation nor did tumor-specific antibodies predict TNP accumulation. Reprinted with permission from [57].
