Figure 4.

Gene set enrichment for genes encompassed in placenta and cancer hypomethylated blocks. (A) Bubble chart representing the enrichment of MsigDB hallmark gene sets in placenta and cancer hypomethylated blocks (colon adenocarcinoma). “Cancer/Placenta” (“Cancer Unique”) represents genes in cancer hypomethylated blocks that co-localize (do not co-localize) with a placenta hypomethylated block. Only the significant enrichments (P-value <0.05) are presented. Networks of genes belonging to cancer/placenta blocks and relating to the (B) “TNF-α signaling via NF-kappa B” gene set and the (C) “UV Response - Down” gene set were identified using IPA software. Abbreviations as in Table 1.