Table 1.
Large blocks of differential methylation in placenta and cancer tissues.
| Number of Blocks (N) | Genomic Size (Mb) | Prop. Hypo. Blocks (%) | Med. Diff. Methylation (%) | |
|---|---|---|---|---|
| First trimester vs. Third trimester | ||||
| Chorionic villi (CHVL) | 1240 | 346 | 93 | −10 |
| Malignant vs. Normal | ||||
| Bladder urothelial carcinoma (BLCA) | 1865 | 887 | 99 | −11 |
| Breast invasive carcinoma (BRCA) | 2195 | 774 | 52 | −5 |
| Colon adenocarcinoma (COAD) | 1978 | 843 | 81 | −8 |
| Esophageal carcinoma (ESCA) | 965 | 306 | 94 | −9 |
| Head and neck squamous cell carcinoma (HNSC) | 2099 | 916 | 73 | −7 |
| Liver hepatocellular carcinoma (LIHC) | 1856 | 1078 | 99 | −12 |
| Lung adenocarcinoma (LUAD) | 1620 | 593 | 72 | −6 |
| Lung squamous cell carcinoma (LUSC) | 2063 | 966 | 84 | −8 |
| Pancreatic adenocarcinoma (PAAD) | 1058 | 212 | 81 | −6 |
| Prostate adenocarcinoma (PRAD) | 2105 | 568 | 26 | 3 |
| Rectum adenocarcinoma (READ) | 1183 | 422 | 100 | −15 |
| Thyroid carcinoma (THCA) | 1752 | 422 | 20 | −3 |
| Uterine corpus endometrioid carcinoma (UCEC) | 2041 | 686 | 76 | −8 |
Prop. Hypo. Blocks (%): proportion of hypomethylated blocks in percent. Med. Diff. Methylation (%): median of the average difference between first and third trimester/malignant and normal.