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Changes in renal responses. Change from baseline±SEM in urinary sodium clearance (UNaV; A), fractional excretion of sodium (FeNa; B), free water clearance (FWC; C), and urinary excretion of NO metabolites (UNOxV; D) after treatment with placebo (blue line) and big endothelin-1 (ET-1; red line). *P<0.05, **P<0.01, and ****P<0.0001 for placebo vs big ET-1 (ANOVA plus Bonferroni correction for significance at specific time points).
