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. 2017 Dec 18;13:1–18. doi: 10.2147/IJN.S144155

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© 2018 Celluzzi et al. This work is published and licensed by Dove Medical Press Limited

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Agarose gel electrophoresis of polymer-coated CNTs complexed with a synthetic DNA.

Notes: Agarose gel (1%) stained with Hoechst 33258 shows that (A) PEI-coated and PAMAM-coated CNTs are able to bind DNA (10:1 w/w) (lanes 7–9 and 14–16) similar to starting polymers (lanes 3–6 and 10–13) but at a different weight ratio. DNA ladder (50 bp) was loaded in lane 1 and a well-characterized DNA fragment (∼250 bp) in lane 2. The heparin competitive assay (B) indicates that the nucleic acid bound to PAM-CNTs is more easily released (lanes 10–12), compared to PEI-CNTs (lanes 5–7 and 13–15), whereas supPEI-CNTs and supPAM-CNTs can bind nucleic acid more strongly compared to their CNT counterparts.

Abbreviations: CNTs, carbon nanotubes; CTR, control; PAMAM, polyamidoamine dendrimer; PEI, polyethyleneimine.