Figure 5.

Effects of SEYG in human prostate cancer cells growth in nude mice induced by DU145. (A) Schematic representation of experimental protocol described in “Materials and Methods.” DU145 cells (4 × 10⁶ cells/mice) were injected subcutaneously into the right flank of the mice. The animals were randomized after 1 week of tumor cell injection into 3 groups based on tumor volume. Group I was given PBS (200 µL, ip thrice/week), group II was given SEYG (50 mg/kg body weight, ip thrice/week), and group III was given SEYG (200 mg/kg body weight, ip thrice/week). (B) Necropsy photographs of mice bearing subcutaneously implanted prostate tumors. (C) Tumor volumes in mice measured during the course of experiment and calculated using the formula V = 4/3πr³, ** indicates P < .01. (D) Tumor volumes in mice measured on the last day of the experiment at autopsy using Vernier calipers and calculated using the formula V = 4/3πr³ (n = 11). Columns, mean; bars, SD. (E) Tumor weight was measured at the end of the experiment. Columns, mean; bars, SD.