Figure 1.
β-Lapachone decreases viability of metastatic murine colon carcinoma cells. (A) Chemical structure of β-lapachone. (B and C) Viability of β-lapachone-treated CT26 and MC38 cells. Cells were seeded at a density of 3 × 103 cells/well in 96-well microplates and then treated with various concentrations of β-lapachone for 24 and 48 hours. After incubation at 37°C, cell viability was determined using the WST assay. Results are expressed as the mean ± SD of 3 independent experiments. **P < .01, ***P < .001. (D) Morphology of β-lapachone-treated CT26 cells. After 24 hours of incubation with β-lapachone, photographs were acquired by microscopy. The photographs are representative of 3 independent experiments.