Table 1.
Selection of PRRL Substances and Manufacturers.
| PRRL (Receptor) | Manufacturer | GMP/GLP |
|---|---|---|
| CRX-527, CRX-675 (TLR-4) | Corixa/GSK | GMP |
| CpG ODN (TLR-9) | Invivogen | GLP |
| dSLIM (TLR-9) | Mologen | GMP |
| E5564 (TLR-4) | Eisai | GMP |
| Imiquimod (TLR-7/8) | Invivogen | GLP |
| Loxoribine (TLR-7) | Invivogen | GLP |
| LPS (TLR-4) | Sigma/Medgamal | GLP/GMP |
| LTA Staphylococcus aureus (TLR-2/6) | Sigma | GLP |
| MALP-2 (TLR-1/2) | Enzo | GMP |
| MPL (TLR-4) | Corixa/GSK | GMP |
| PAM2CSK4 (TLR-2/6) | Invivogen | GLP |
| poly-AU (TLR-3) | Ipsen-Beaufour | GMP |
| poly-ICLC (TLR-3) | Hiltonol/Oncovir | GMP |
| poly-Us21+DOTAP (TLR-7) | Innate Pharma | GMP |
| Resiquimod (TLR-7/8) | Enzo | GMP |
| Vaximmune (TLR-9) | Coley-Pharma/Aventis | GMP |
| Zymosan (Dectin-1, TLR-2) | Invivogen | GLP |
| Stimuvax (contains MPL, TLR-4) | Biomira/Merck | GMP |
Abbreviations: PRRL, pattern recognition receptor ligands; GMP, good manufacturing practice; GLP, good laboratory practice.