Table 2.
Approved Drugs Most Likely Containing PRRLs, Judged by Content and Side Reactions Described in the Respective Instruction Leaflets.
| Brand | Manufacturer | Ingredients | Main Indication | Fever Reported as Adverse Event | Approved for Cancer Therapy |
|---|---|---|---|---|---|
| BCG vaccine | CC-Pharma Medac | Attenuated live Mycobacterium bovis | Vaccine | Yes | Yes |
| Broncho-Vaxom | Eurim Pharm | Lyophilized bacterial extract from Haemophilus influenzae, Diplococcus pneumoniae, Klebsiella pneumoniae and K ozeanae, Staphylococcus aureus, Streptococcus pyogenes and viridans, Neisseria catarrhalis | Respiratory infections | No | No |
| CADI05 | Immuvac | Autoclaved Mycobacterium indicus pranii | Leprosy | Yes | Yes |
| Cholera vaccine | Wyeth | Inactivated cholera bacteriae | Vaccine | Yes | No |
| Colibiogen inject | Laves | Metabolic products from Escherichia coli laves | Colon infections | No | Yes |
| Detox | Biomira Inc | MPL (monophosphoryl-lipid-A) and cell wall extracts from Mycobacterium phlei | Adjuvant | Yes | No |
| Flulaval | GSK | Inactivated influenza virus | Vaccine | Yes | No |
| Iscador | Weleda | Mistletoe extract | Immune stimulant | Yes | Yes |
| Ixiaro | Novartis-Behring | Inactivated Japanese encephalitis virus | Vaccine | Yes | No |
| JE-VAX | Sanofi-Pasteur | Inactivated Japanese encephalitis virus | Vaccine | Yes | No |
| Lektinol | Rottapharm | Mistletoe lectin | Cancer | Yes | Yes |
| MPL | Corixa | MPL from Salmonella minnesota | Adjuvant | No | No |
| Picibanil | Chugai | Lyophilized Streptococcus pyogenes | Cancer | Yes | Yes |
| Pollinex | Bencard | Pollen allergens and MPL | Allergies | No | No |
| Polyvaccinum forte | IBSS biomed (Poland) | Inactivated extract from Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus salivarius, Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli, K pneumoniae, H influenzae, Corynebacterium pseudodiphtheriticum, Moraxella catarrhalis | Chronic and recidivistic inflammatory process of the respiratory tract, bladder and endometrium | Yes, up to 8 hours | No |
| Pyrogenalum | Medgamal (Russia) | LPS from Salmonella typhi | Nerve trauma, prostatitis, uretritis, uveitis, latent TBC | Yes, up to 8 hours | No |
| StroVac | Strathmann | Inactivated Escherichia coli, Morganella morganii, Proteus mirabilis, K pneumoniae, Enterococcus faecalis | Recidivistic bladder inflammation | Yes, up to 40°C | No |
| Typhoral | Novartis-Behring | Salmonella typhi; apathogenic live germs | Vaccine | Yes | No |
| YF-VAX | Sanofi-Pasteur | Yellow fever virus | Vaccine | Yes | No |
| Zylexis | Pfizer | Inactivated Parapoxvirus ovis | Veterinary drug, immune stimulant | No | No |
Abbreviations: PRRL, pattern recognition receptor ligands; LPS, lipopolysaccharide.