Figure 3.

In vivo therapeutic efficacy of Icar-MC in mice bearing MCF-7/ADR xenograft. (A) Mice with representative tumor xenografts are shown. (B) Mean tumor volumes as functions of time. Arrows indicate the last treatment at day 24 and the end of the experiment at day 34. Empty micelles were injected intravenously at 100 mg/kg. (C) Examples of the transverse sections of high-resolution magnetic resonance images of the tumor xenografts were shown here for illustration. Arrows, tumor location. (D) Body weight changes for the tumor-bearing mice after various formulations were given to mice on the indicated days.